The Genetic Landscape of Frontotemporal Dementia

Frontotemporal dementia (FTD) often features genetic mutations that are crucial for understanding its presentation and implications. Among these mutations, C9ORF72, progranulin, and MAPT have been identified as the most prevalent. Genetic testing for these mutations is vital, as about a third of FTD patients carry a pathogenic variant, which is significantly higher than in Alzheimer's disease where genetic forms are rare. Recognizing these genetic factors is essential not only for diagnosis but also for potential treatment avenues and familial support.