Exchanges at the Frontier: 08Feb14 - Bonnie Bassler
Feb 7, 2014
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Molecular biologist Bonnie Bassler, a world specialist in how bacteria communicate within the human body, discusses the key to solving the antibiotic problem and her groundbreaking discoveries in bacterial communication. Topics covered include the fascinating world of bacteria, their roles in our bodies, the concept of quorum sensing in bacterial communication, challenges posed by harmful bacteria and antibiotic resistance, and potential alternative strategies for treating bacterial infections.
Bacteria can communicate with each other through quorum sensing, allowing them to coordinate their behavior and potentially be targeted with antibacterial therapies.
Bacteria are essential for human survival, providing enzymes, proteins, and functions that our own cells cannot produce, but understanding bacterial communication can help differentiate between beneficial and harmful bacteria.
Quorum sensing in bacteria, which is the precursor to more complex forms of communication in multi-cellular organisms, may hold the key to understanding the basic rules of communication and coordination in higher organisms.
Deep dives
Bacteria as Communicators
Bacteria have the ability to communicate with each other using a chemical language. This process, known as quorum sensing, allows bacteria to coordinate their behavior and work as a collective. It was originally discovered in a species of bioluminescent bacteria associated with the bobtail squid. The bacteria release molecules called auto-inducers, which increase in concentration as the bacterial population grows. Once the auto-inducer concentration reaches a certain threshold, the bacteria act in unison, such as producing light or releasing toxins. Quorum sensing is seen in many different types of bacteria, and the molecules involved can differ for communication within the same species, between different species, or even between beneficial and harmful bacteria. Manipulating quorum sensing has the potential to be used in antibacterial therapies.
The Role of Bacteria in the Human Body
Bacteria are not just harmful organisms, but are crucial for human survival. In fact, humans have more bacterial cells than human cells. These bacteria play an active role in keeping us alive by providing enzymes, proteins, and functions that our own cells cannot produce. They help with digestion, vitamin production, immune system education, and protection. Most bacteria we encounter are beneficial and essential for our well-being. However, there are harmful bacteria that can cause disease when they get out of control or invade areas where they shouldn't be. Understanding how bacteria communicate with each other through quorum sensing can help us differentiate between good and bad bacteria and develop targeted therapies to combat harmful bacteria.
The Evolutionary Significance of Bacterial Communication
Quorum sensing and collective behavior in bacteria are believed to be the evolutionary precursors to more complex forms of communication found in multi-cellular organisms. Bacteria were the first living organisms on Earth and have developed sophisticated mechanisms to communicate with each other over billions of years of evolution. While the molecules and mechanisms used by bacteria are more primitive compared to higher organisms, the underlying principles of synchrony and unified group behavior were originally invented by bacteria. This suggests that the basic rules of communication and coordination in multi-cellular organisms may have originated from bacteria.
Manipulating Bacterial Communication for Medical Applications
Research on quorum sensing has the potential to revolutionize the field of medicine, particularly in the development of new antibiotics and therapies to combat bacterial infections. By understanding and manipulating bacterial communication, it may be possible to disrupt or interfere with harmful bacteria's ability to coordinate their attacks, thus rendering them harmless or easier to target with current antibiotics. Researchers are working on developing molecules that can interfere with quorum sensing, either by mimicking or inhibiting the natural communication molecules used by bacteria. While this field of research still requires further development and testing, the potential to use bacterial communication as a target for medical intervention offers new hope in the ongoing battle against antibiotic resistance and infectious diseases.
The Future of Bacterial Research and Long-Term Implications
The study of bacterial communication is still a relatively young field, but it holds great promise for the future of medicine and biology. Scientists are continuously exploring new avenues for understanding how bacteria communicate and the impact it has on our health. In addition to the development of novel therapies, ongoing research in bacterial communication can lead to a greater understanding of the human microbiome and its influence on various diseases and conditions. By unraveling the intricacies of bacterial communication, we gain valuable insights into the fundamental mechanisms of life itself. This knowledge can contribute to advancements in medicine, conservation, and other fields, ultimately leading to improvements in human health and the environment.
Bonnie Bassler is the world specialist in how bacteria communicate within the human body. She explains to A.C.Grayling and pupils at Haverstock School, that this process holds the key to solving the problem of failing antibiotics.
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