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World Questions

Exchanges at the Frontier: 08Feb14 - Bonnie Bassler

Feb 7, 2014
Molecular biologist Bonnie Bassler, a world specialist in how bacteria communicate within the human body, discusses the key to solving the antibiotic problem and her groundbreaking discoveries in bacterial communication. Topics covered include the fascinating world of bacteria, their roles in our bodies, the concept of quorum sensing in bacterial communication, challenges posed by harmful bacteria and antibiotic resistance, and potential alternative strategies for treating bacterial infections.
49:41

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Quick takeaways

  • Bacteria can communicate with each other through quorum sensing, allowing them to coordinate their behavior and potentially be targeted with antibacterial therapies.
  • Bacteria are essential for human survival, providing enzymes, proteins, and functions that our own cells cannot produce, but understanding bacterial communication can help differentiate between beneficial and harmful bacteria.

Deep dives

Bacteria as Communicators

Bacteria have the ability to communicate with each other using a chemical language. This process, known as quorum sensing, allows bacteria to coordinate their behavior and work as a collective. It was originally discovered in a species of bioluminescent bacteria associated with the bobtail squid. The bacteria release molecules called auto-inducers, which increase in concentration as the bacterial population grows. Once the auto-inducer concentration reaches a certain threshold, the bacteria act in unison, such as producing light or releasing toxins. Quorum sensing is seen in many different types of bacteria, and the molecules involved can differ for communication within the same species, between different species, or even between beneficial and harmful bacteria. Manipulating quorum sensing has the potential to be used in antibacterial therapies.

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