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To effectively maintain weight loss achieved through a drug like Ozempic, it is crucial to focus on retaining muscle mass and ensuring adequate protein intake. The podcast emphasizes that losing weight without preserving muscle mass can lead to a significant reduction in muscle percentage, impacting overall body composition. Therefore, it stresses the importance of consuming bioavailable protein sources like animal proteins such as red meat, eggs, and fish. Additionally, the discussion highlights the necessity of balancing hormone levels, especially during natural processes like menopause, where hormonal changes can affect muscle retention. Ensuring sufficient protein intake and engaging in regular exercise are highlighted as key strategies to maintain muscle mass effectively.