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Big Biology

The time of your life (Ep 117)

Mar 7, 2024
In this podcast, Rosemary Braun discusses studying complex biological networks, circadian rhythms, and using machine learning to target treatments based on individual circadian rhythm. The episode explores the search for undiscovered rules in biology, dynamics of gene expression networks, resilience in circadian clockkeeping, and the impact of genetic variations on gene regulation.
25:53

Episode guests

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Quick takeaways

  • Uncovering new principles governing living systems beyond traditional rules of life through computational biology and whole system analytical approaches.
  • Studying how network configurations influence physiological states like sleep-wake cycles and disease development, emphasizing robustness and adaptability in networks.

Deep dives

Rules of Life - Reevaluating the Known Rules of Life

The traditional rules of life emphasize fundamental concepts like cells composing living things, the use of DNA for inheritance, homeostasis, and evolution. Rosemary Brown challenges this view by suggesting the existence of additional undiscovered rules of life. Her computational biology expertise aims to uncover new principles governing living systems beyond the known paradigms. By leveraging vast data sets and whole system analytical approaches, Brown explores how living networks organize and respond to internal and environmental changes, potentially unveiling novel rules of life.

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