For World PICU Day on May 12, 2023, The World Federation of Pediatric Intensive and Critical Care Societies (WFPICCS) organized a panel discussion with regional speakers discussing Sepsis guidelines for early recognition, resuscitation, and management: Global perspectives. The panelists provided a brief summary of: • Their participation in the development of the implementation of guidelines for use in facilities for either recognition, resuscitation or management of sepsis. • ONE success in either the development or implementation of sepsis guidelines in their institution. • ONE challenge/ failure in either the development or implementation of sepsis guidelines in their institutions. Introduction: Brenda Morrow, PhD, BSc Physiotherapist/Professor Department of Paediatrics University of Cape Town (UCT) Cape Town, South Africa Moderator: Mark Ansermino MBBCh, MMed, MSC, FFA (SA), FRCPC Investigator, BC Children's Hospital Director, Centre for International Child Health, BC Children's Hospital Vancouver, BC, Canada Panelists: John Adabie Appiah MBChB, MWACP, MGCPS, Cert. Crit. Care, MPhil Crit. Care (UCT) Senior Specialist and Founding Head of PICU Komfo Anokye Teaching Hospital Kumasi, Ghana Werther Bruno de Carvalho MD, PhD, FCCM Professor of Pediatric Intensive Care/Neonatology Department of Pediatrics Faculty of Medicine - University of São Paulo São Paulo, Brazil Ener Çağri Dinleyici MD, PhD Eskisehir Osmangazi University Faculty of Medicine Department of Pediatrics Eskisehir, Turkey Cintia Johnston RRT, MsC, PhD Physiotherapist Clinical Research Assistent Professor of Neonatology and Intensive Care Pediatrics Department Medical University of São Paulo - FMUSP São Paulo, Brazil Teresa Bleakly Kortz MD, MS, PhDc Pediatrician and Assistant Clinical Professor, Division of Pediatric Critical Care Associate Professor of Clinical Pediatrics in Critical Care Medicine Affiliate Faculty of the Institute for Global Health Sciences Co-director of the Pediatric Global Health Pathway,UCSF San Francisco, California, USA Suchitra Ranjit MD, FCCM Head of the Department of Pediatric Emergency and Critical Care Apollo Children's Hospital Chennai, India Gerri Sefton PhC, MSc, BSc, RGN/RSCN Advanced Nurse Practitioner/PICU Alder Hey Children's Hospital Liverpool, England, United Kingdom