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Part 1 of 4: Jon Chee hosts Barry Ticho, Founder of Verve Therapeutics and Chief Medical Officer at Stoke Therapeutics, a biotech company addressing the underlying cause of severe diseases by upregulating protein expression with RNA-based medicines.

With an MD-PhD from the University of Chicago and extensive experience across academia and industry, Barry brings over two decades of expertise in clinical development. His journey includes roles as Head of Development at Moderna, Head of External R&D Innovation at Pfizer, and VP of Clinical Development at Biogen, where he's been instrumental in advancing numerous therapeutic programs across multiple disease areas.

Barry's unique perspective spanning academic medicine and biotechnology innovation makes his insights invaluable for aspiring leaders in the field.

Please enjoy Jon’s conversation with Barry Ticho.

Subscribe to the podcast: https://podcasts.apple.com/us/podcast/the-biotech-startups-podcast/id1679591994

https://www.linkedin.com/in/barryticho/ 

https://www.stoketherapeutics.com/ 

https://www.vervetherapeutics.com/ 

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Podcast Website: https://www.thebiotechstartupspodcast.com/
 

Stoke Therapeutics https://www.stoketherapeutics.com/ 

Verve Therapeutics https://www.vervetherapeutics.com/ 

Moderna https://www.modernatx.com/ 

Pfizer https://www.pfizer.com/ 

Biogen https://www.biogen.com/ 

Ophthalmology https://en.wikipedia.org/wiki/Ophthalmology 

Haverford University https://www.haverford.edu/ 

University of Chicago https://www.uchicago.edu/en 

Harvard Medical School https://hms.harvard.edu/ 

Boston Children's Hospital https://www.childrenshospital.org/ 

How to Spin Out of Academia: https://www.excedr.com/resources/how-to-spin-out-of-academia-and-into-a-startup

Patent Licensing for Biotechs: https://www.excedr.com/resources/how-patent-licensing-works

Biotech Startup Support: https://www.excedr.com/resources-category/biotech-startup-support

Phil Sharp https://en.wikipedia.org/wiki/Phillip_Allen_Sharp 

Murray Rabinowitz https://www.nasonline.org/wp-content/uploads/2024/06/rabinowitz-murray.pdf 

00:00 Intro

03:04 Barry's background and introduction

03:37 Growing up in a family of Holocaust survivor physicians

05:29 Four out of five brothers choosing medicine

07:14 Early exposure to ophthalmology and patient care

09:27 The transformative moment: witnessing a child regain sight

12:45 Choosing Haverford and discovering biology

14:06 Early laboratory experiences and liberal arts education

19:05 The path to University of Chicago's MD-PhD program

22:13 First research experiences with RNA and transcription

23:55 Graduate school years: freedom and scientific method

30:15 Mentorship style and thesis advisor's influence

33:05 Leadership lessons from graduate training

36:28 Outro

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