1) Atrial fibrillation and unexplained stroke and 2) Topic of the month: Stroke trials. This podcast for the Neurology Journal begins and closes with Dr. Robert Gross, Editor-in-Chief, briefly discussing highlighted articles from the print issue of Neurology. In the second segment Dr. Bryan Eckerle interviews Dr. Paul Cotter about his paper on incidence of atrial fibrillation and unexplained stroke. Dr. Adam Numis is reading our e-Pearl of the week about LGI-1 antibodies in limbic encephalitis. In the next part of the podcast Dr. Brett Kissela interviews Drs. Opeolu Adeoye and Art Pancioli about the CLEAR-ER trial. The participants had nothing to disclose except Drs Cotter, Numis, Kissela and Adeoye.Dr. Cotter receives research support from the UK National Institute for Health Research, Cambridge biomedical Research Center and Clinical Research Fellowship.Dr. Numis serves on the editorial team for the Neurology® Resident and Fellow Section. Dr. Kissela serves on scientific advisory board for Allergan, Inc.; has received funding for travel and speaker honoraria from Allergan, Inc.; has received research support from the NIH, will receive compensation from Reata Pharmaceuticals, Inc. for serving on the Event Adjudication Committee for the BEACON study, which they are sponsoring. and provides medico-legal reviews.Dr. Adeoye received honoraria for serving on the speakers' bureau of Genentech, Inc. and receives research support from the NIH.