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JAMA Editors' Summary
Vitamin C for COVID-19, Stool Test for Colorectal Cancer Screening, USPSTF on Oral Health, and more
Nov 14, 2023
This podcast discusses the lack of efficacy of intravenous vitamin C for COVID-19 patients. It also covers a phase 3 trial on a multitarget stool RNA test for colorectal cancer screening and the prevalence of Acinetobacter and Candida in ventilated patients. Furthermore, it highlights various research letters, editorials, and viewpoints published in the latest issue of JAMA, covering a wide range of healthcare topics. Lastly, it includes topics on oral health screening, topical therapies for atopic dermatitis, and over the counter progestin-only oral contraceptives.
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Quick takeaways
- Intravenous vitamin C had a low probability of improving outcomes for COVID-19 patients and a high probability of worsening outcomes.
- The multitarget stool RNA test demonstrated a high sensitivity for detecting colorectal cancer and advanced adenomas while maintaining specificity.
Deep dives
Investigating the Efficacy of Intravenous Vitamin C for COVID-19 Patients
Two randomized clinical trials examined the effects of intravenous vitamin C on hospitalized adults with COVID-19. The trials included both critically ill and non-critically ill patients and enrolled over 1,500 critically ill patients and more than 1,000 non-critically ill patients. The results showed that by 21 days, vitamin C had a low probability of improving the primary composite outcome of organ support free days and survival to hospital discharge, and a high probability of worsening outcomes in both critically and non-critically ill patients.
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