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The Curious Clinicians
[Archive] Of Ticks, Alpha-gal, and Red Meat Allergies
Dec 20, 2023
Exploring the unexpected connection between tick bites and red meat allergies, discussing the role of the alpha-gal sugar molecule, evolution, and xenotransplantation. Discovering the link dating back to 1991, prevalence in the southeastern US, and how lone star ticks transfer alpha-gal to humans. Touching on allergic reactions to red meat, cetuximab, and challenges of xenotransplantation. Discussing the creation of alpha-gal knockout animals for organ transplantation, successful pig heart xenotransplantation, and availability of meat from genetically modified pigs for those allergic to alpha-gal.
21:22
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Quick takeaways
- The discovery of alpha-gal in ticks links to red meat allergies, highlighting an unusual source of an allergic reaction trigger.
- The absence of the enzyme to synthesize alpha-gal in humans suggests an evolutionary defense against animal viruses, causing meat allergies.
Deep dives
The Link Between Tick Bites and Meat Allergies
Tick bites, particularly Lone Star ticks in the US Southeast, have been associated with red meat allergies. The podcast delves into the surprising discovery of an alpha-gal sugar moiety found in ticks and its role in inducing allergic reactions to red meat. Through case studies, it was revealed that exposure to alpha-gal via tick bites sensitizes individuals to alpha-gal present in meat, leading to severe allergic reactions like hives and anaphylaxis.
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Discover
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