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#92 – Antibiotic Alchemy: Metallo-Beta-Lactamases
Feb 2, 2024
Delving into the world of metallo-beta-lactamases, the podcast explores novel beta lactams, inhibitors, and their uses for MBLs. The discussion is packed with nerdy pub trivia and essential details on combatting gram-negative resistance. Global spread of metallo-beta-lactamases, next-gen inhibitors, and complex treatment challenges post liver transplant are also discussed.
01:10:30
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Quick takeaways
- MBL inhibitors face structural challenges due to zinc ions in the active site.
- Combining beta-lactamase inhibitors with beta-lactam antibiotics is a common approach to combat MBL resistance.
Deep dives
Metallo Beta-Lactamases: An Overview
Metallo beta-lactamases (MBLs) are a class of enzymes that break down beta-lactam antibiotics, but they have unique characteristics compared to other beta-lactamases. MBLs contain a zinc ion in their active site, giving them a distinct structure and mechanism of action. They are categorized into different subclasses, with B1 being the most clinically significant. MBLs can be found in various gram-negative bacteria, including Enterobacteriaceae, Pseudomonas, and Acinetobacter. The global epidemiology of MBLs shows higher prevalence in Southeast Asia, the Middle East, and certain parts of Europe. In North America, the prevalence of MBLs is relatively low but increasing. The diversity and evolution of MBLs pose challenges for treatment and development of inhibitors.
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