High Intensity Health with Mike Mutzel, MS

Longevity Scientist Shares Top Strategies for Improving Your Health Span w/ Matt Kaeberlein, PhD

Sep 6, 2024

Matt Kaeberlein, PhD, a longevity scientist and CEO of Optispan, dives into the cutting-edge world of health span enhancement. He discusses the pivotal roles of mTOR signaling, dietary protein, and exercise in muscle preservation as we age. Kaeberlein explores the potential benefits of rapamycin, spermidine, and NAD precursors for longevity while cautioning against common myths like resveratrol as a magic solution. He also highlights the impact of lifestyle factors—like obesity and alcohol consumption—on overall health and aging.

01:29:44

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Matt Kaeberlein

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Quick takeaways

The rise in obesity rates since the 1970s emphasizes the critical role of environmental factors in shaping public health outcomes.

A balanced approach to managing mTOR through diet and exercise can optimize healthspan and mitigate cellular aging.

Social connections are vital for longevity; fostering relationships can significantly improve overall wellbeing and combat loneliness.

Deep dives

Environmental Changes and Obesity Trends

The discussion highlights a significant shift in obesity rates among Americans since the 1970s, noting that more than 50% of the population is now considered obese, a dramatic rise compared to previous decades when obesity was rare. This change is attributed purely to environmental factors, asserting that genetic predispositions have remained constant over the years. The speaker emphasizes the importance of recognizing these environmental influences on health, arguing that lifestyle choices, including diet and physical activity, have a profound impact on overall health outcomes. The issue of rising obesity not only affects individual health but also has broader implications for public health and healthcare systems.

The Intricacies of mTOR Signaling in Aging and Muscle Health

02:11

Exploring the Foundations of Health Span Optimization

02:51

Intro

3min

Exploring Longevity and Social Connections

9min

mTOR Signaling and Aging

7min

Evaluating the Health Impact of Protein Sources

2min

Exploring Rapamycin and Longevity Factors

16min

Exploring Longevity: Alcohol, Supplements, and Biological Aging

27min

Understanding Immune Senescence and P16

12min

Exploring Rapamycin: Dosing and Health Implications

16min

Today’s show is brought to you by MYOXCIENCE Nutrition. In this episode Matt Kaeberlein, PhD, CEO of Optispan, discusses the significance of enhancing health span through interventions like rapamycin and highlights the role of senescent cells in chronic inflammation and age-related diseases.

Crush your workouts with the Creatine+ Electrolyte Combo by MYOXCIENCE: https://bit.ly/Electrolyte-Stix-Jar *Save with code podcast at checkout

Link to show notes: https://bit.ly/4gdmxES

Key Takeaways:

02:44 Pillars of health: eat, sleep, move, connect.
10:30 Eating protein and exercise can turn up mTOR.
15:20 High dietary protein and resistance training preserves muscle while aging.
19:20 Longevity research is underfunded.
25:10 Obesity was rare 50 years ago.
26:25 Fasting, and time restricting eating may not increase longevity.
30:45 Smoking, sedentary life, alcohol consumption and obesity shorten lifespan.
34:40 Resveratrol is not a longevity drug.
36:45 Spermidine is an autophagy booster.
38:10 Alpha ketoglutarate, urolithin A, and NAD precursors, may increase lifespan.
42:45 Acarbose, SGLT-2 inhibitors, and estrogens can increase lifespan.
44:45 Metformin does not corelate to reduced all-cause mortality.
47:30 NAD is a co-factor required for thousands of metabolic reactions.
52:55 Some epigenetic signatures are predictive of future health outcomes.
54:17 Facial imaging using AI can predict future health outcomes.
58:17 Dunedin Pace measures the rate of aging.
59:40 Optispan looks at epigenetics, blood glycan, and immune resilience/aging.
01:04:00 Senescent cells are cells that do not do their job and refuse to die.
01:07:50 Rapamycin impacts senescent cells, autoimmunity, and inflammation.

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