Why can the sodium-potassium pump work backwards? | Masterjohn Q&A Files #279

Short answer: The second law of thermodynamics means that concentrations of specific chemicals or positive or negative charges will always "want" to disperse and randomly mix in their environment, making concentrations of ions such as sodium or potassium a form of potential energy. While the pump normally uses energy from ATP to invest into creating those concentrations, if ATP levels are low and sodium and potassium are already highly concentrated on opposite sides of the cell membrane, their potential energy can be released by mixing across the membrane, and can be used to synthesize ATP. Watch the video or listen to the podcast with the links below. You can obtain a full transcript of the episode by signing up for the Masterpass at https://chrismasterjohnphd.com/q&a Please consider supporting my work by making a purchase using these links at one of my affiliates: https://chrismasterjohnphd.com/foursigmatic, https://chrismasterjohnphd.com/paleovalley, https://chrismasterjohnphd.com/seekinghealth, https://chrismasterjohnphd.com/ancestralsupplements, https://chrismasterjohnphd.com/magicspoon, https://chrismasterjohnphd.com/lmnt

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Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome