Dr. Kara Fitzgerald | New Frontiers in Functional Medicine, Longevity, Epigenetics Measuring Metabolites of Dysbiosis and Gut Function to Create Targeted Interventions
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Jun 5, 2023 Dr. Erika Ebbel Angle, a biochemist and CEO of Ixcela, dives into the fascinating world of gut microbiome testing. She discusses their innovative fingerstick test that measures 11 key metabolite markers, shedding light on how gut health impacts overall well-being. Erika emphasizes the importance of blood samples over urine and explores how endurance sports and chronic stress influence health markers. From serotonin’s role in mood to purine markers as inflammation signals, this conversation uncovers vital insights for optimizing health through understanding metabolites.
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Metabolomics Pointed To The Gut
- Ixcela selected 11 blood metabolites from decades of metabolomics because they repeatedly tracked disease risk and physiology.
- Surprisingly, most of those key markers arose from gut microbiome activity and host digestion.
Tryptophan Is A Central Metabolic Hub
- Tryptophan sits at the center of multiple gut, brain, immune and sleep pathways and its fate matters greatly.
- Measuring tryptophan and downstream indoles reveals gut diversity, permeability, and neuroimmune signaling.
Restore IPA With Fermented Foods First
- If IPA (indole propionic acid) is low, support Clostridium sporogenes by increasing fermented foods and dietary precursors like ILA.
- If ILA is low or conversion is poor, add ILA-rich fermented foods and work to restore converting bacteria before supplementing IPA.