Sigma Nutrition Radio #402: Prof. Leanne Redman – Pregnancy, Maternal Diet & Intergenerational Transmission of Obesity
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Aug 31, 2021 Prof. Leanne Redman discusses intergenerational transmission of obesity through maternal diet during pregnancy. She explores health issues in women and the correlation between obesity and adverse outcomes. The podcast also covers the urgency of addressing obesity as a global pandemic and the importance of empathy towards individuals dealing with obesity. Lastly, she emphasizes the significance of listening, kindness, and empathy as daily actions for a positive impact.
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Early Origins of Obesity Risk
- Obesity risk can be inherited from parents and even grandparents through genetic and environmental factors during pregnancy.
- Maternal obesity before conception alone increases offspring's risk of excess body fat and obesity later in life.
Metabolic Health Over BMI Alone
- Maternal metabolic milieu, including glucose and triglycerides levels, better predicts offspring adiposity than obesity alone.
- Metabolically unhealthy obesity with prolonged high substrate exposure leads to higher fetal fat than obesity without these metabolic risks.
Cumulative Metabolic Exposure Matters
- Fetuses exposed to high maternal metabolic risk factors for longer durations develop almost double the adiposity at birth.
- It is the cumulative exposure throughout pregnancy, captured as area under the pregnancy curve, that influences fetal fat accumulation.