Bloody Minded Episode 26 - Trip to the Congo | Amyloidosis Overview
Dec 3, 2024
Explore the intricate world of amyloidosis and its bewildering subtypes that boggle even seasoned professionals. Delve into the nuances of wild type transthyretin amyloid and its stealthy health impacts, along with the essential imaging techniques for accurate diagnosis. Learn about the complexities of AL amyloidosis treatment and the challenges posed by existing deposits. Plus, enjoy a light-hearted discussion on the common confusions surrounding this protean disease, ensuring listeners come away informed and entertained!
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Amyloidosis Pathophysiology Simplified
- Amyloidosis is caused by extracellular deposition of misfolded protein clumps called amyloid fibrils.
- These deposits disrupt normal organ function, leading to diverse disease presentations based on protein type.
Main Amyloid Subtypes Overview
- Four main amyloidosis subtypes are AL, AA, AB2M, and ATTR based on the protein involved.
- Hematologists mainly manage AL amyloidosis, but cardiologists and nephrologists are important for other types.
Chronic Inflammation Leads to AA Amyloid
- AA amyloidosis arises from chronic inflammation causing excess serum amyloid A proteins.
- It's common in developing countries due to infections and in Western countries due to autoimmune diseases.