1) Prevention of new brain lesions and 2) Topic of the month: AAN Plenary Sessions. This podcast for the Neurology Journal begins and closes with Dr. Robert Gross, Editor-in-Chief, briefly discussing highlighted articles from the print issue of Neurology. In the second segment Dr. Pearce Korb interviews Dr. David Mohr about his paper on stress management for the prevention of new brain lesions. Dr. Jennifer Fugate is reading our e-Pearl of the week about Panayiotopoulos syndrome. In the next part of the podcast Dr. Alberto Espay interviews Dr. Chris Austin about his plenary session on translational therapeutics development at NIH. The participants had nothing to disclose except Drs. Mohr, Fugate, and Espay.Dr. Mohr is a consultant for the NIH and receives research support from NIH.Dr. Fugate serves on the editorial team for the Neurology® Resident and Fellow Section. Dr. Espay is supported by the K23 career development award (NIMH, 1K23MH092735); has received grant support from CleveMed/Great Lakes Neurotechnologies, Davis Phinney Foundation, and Michael J Fox Foundation; personal compensation as a consultant/scientific advisory board member for Solvay Pharmaceuticals, Inc., Abbott, Chelsea Therapeutics, TEVA Pharmaceutical Industries Ltd, Impax Pharmaceuticals, Solstice Neurosciences, and Eli Lilly and Company; and honoraria from Novartis, the American Academy of Neurology, and the Movement Disorders Society. He serves as Assistant Editor of Movement Disorders and on the editorial boards of The European Neurological Journal and Frontiers in Movement Disorders.