The Complexities of Pleiotropy and Supplements in Longevity

If you haven’t heard of the Don’t Die movement or Bryan Johnson’s Blueprint Protocol, then buckle in.

Johnson is a millionaire who is pouring his money into a massive effort to stay as young as possible, for as long as possible.

Norman and Tegan unpack the basics of his routine, and some of his whackier attempts to turn back the biological clock.

References:

• DunedinPACE, a DNA methylation biomarker of the pace of aging
• How old are you really? Are the latest ‘biological age’ tests all they’re cracked up to be?
• Plasma-Based Strategies for Therapeutic Modulation of Brain Aging
• Infusion of young donor plasma components in older patients modifies the immune and inflammatory response to surgical tissue injury: a randomized clinical trial | Journal of Translational Medicine
• Old plasma dilution reduces human biological age: a clinical study
• Metformin as Anti-Aging Therapy: Is It for Everyone?
• Targeting ageing with rapamycin and its derivatives in humans: a systematic review - The Lancet Healthy Longevity
• A Phase 1/2a Follistatin Gene Therapy Trial for Becker Muscular Dystrophy
• Follistatin Gene Therapy Improves Ambulation in Becker Muscular Dystrophy

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