Your cells are starving. Not for food—but for oxygen.
In this episode of The Human Upgrade, Dave Asprey sits down with Dr. Jason Sonners, world-renowned hyperbaric expert and regenerative medicine pioneer, to reveal how controlled oxygen under pressure is becoming one of the most powerful tools in anti-aging and performance science.
You’ll learn how hyperbaric oxygen therapy (HBOT) triggers stem cell activation, rewires your epigenome, boosts mitochondrial energy, and reverses biological aging—if you use it the right way. Jason shares breakthrough findings from his latest PhD research comparing low- and high-pressure chambers, with surprising results on inflammation, telomeres, cognitive performance, and recovery speed.
This is next-gen longevity—measurable, stackable, and customizable. From sleep upgrades and HRV boosts to stacking HBOT with fasting, methylene blue, or red light, this episode dives into what it takes to oxygenate your biology at the deepest level.
You’ll Learn:
• How hyperbaric oxygen therapy (HBOT) triggers stem cell regeneration and cellular repair
• Why mild-pressure chambers may be more powerful than you think
• What HBOT does to inflammation, brain fog, and biological aging markers
• How to stack HBOT with fasting, red light, and methylene blue for amplified results
• What Dr. Sonners’ PhD research reveals about oxygen pressure and genetic expression
• The truth about oxygen toxicity—and how to avoid the common mistakes
• How elite performers use HBOT for brain optimization, recovery, and resilience
** Get 30% of yourr tickets to the Biohacking conference by going to https://biohackingconference.com/2025 and use code ‘OXYHEALTH’ **
Thank you to our sponsors!
-Our Place | Head to https://fromourplace.com/ and use the code DAVE for 10% off your order.
-Timeline | Head to https://www.timeline.com/dave to get 10% off your first order.
Resources:
• Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/
• Jason's Website – www.hbotusa.com
• OxyHealth Website: https://www.oxyhealth.com/
• 2025 Biohacking Conference: https://biohackingconference.com/2025
• Danger Coffee: https://dangercoffee.com
• Dave Asprey’s Website: https://daveasprey.com
• Dave Asprey’s Linktree: https://linktr.ee/daveasprey
• Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com
• Own an Upgrade Labs: https://ownanupgradelabs.com
• Upgrade Labs: https://upgradelabs.com
• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com
Timestamps:
• 00:00 Trailer
• 01:59 Intro
• 03:14 New research on aging and oxygen
• 05:39 Mild vs. hard-shell chambers
• 13:05 HBOT for longevity and stem cells
• 16:43 How to optimize your sessions
• 22:35 Best therapies to stack with HBOT
• 25:40 Oxygen delivery and safety
• 26:43 Altitude and chamber effects
• 30:01 Key benefits of hyperbaric therapy
• 34:22 Supplement synergy and timing
• 37:25 Pressure and oxygenation findings
• 39:27 Medical vs. welding oxygen
• 44:57 Safety myths and toxicity risks
• 47:39 Future of biohacking with oxygen
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