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The Science of MDMA & Its Therapeutic Uses: Benefits & Risks
Huberman Lab
The Effects of MDMA on Neuronal Activity
Dopamine is a neuromodulator. It can either increase or decrease the activity of other neurons. Neurons release chemicals at their sites of communication, which are called synapses. The methamphetamine component of MDMA gets into what we call the presynaptic neuron and it interferes with the repackaging of dopamine in those vesicles. A bunch of dopamine builds up in the presynptic neuron so that when an electrical impulse comes down that neuron and dopamine is released, a huge amount of dopamine is released. And this is one of the characteristic properties of methamphetamine and of MDMA, which is that it leads to enormous increases in the amount of dopamine released.
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