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TWiV 1221: Nonsense mediated decay

This Week in Virology

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Genetic Insights into Vaccine Responses

This chapter delves into the complexities of studying endemic coronaviruses in mice and the implications of genetic deficiencies in the interferon alpha receptor for vaccine reactions. It discusses live attenuated vaccines and the impact of genetic backgrounds on adverse reactions, emphasizing the importance of informed discussions about vaccination safety. Through detailed case studies and genetic analysis, the chapter uncovers novel mutations linked to immune deficiencies, enriching the understanding of immune response variability.

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