The Brainbow: A Mouse That Picks a Color

In the original paper, I think they could pick between several dozen colors. The cool thing is that if a cell divides and has two daughters, it's going to keep the color of the mother. And we thought, okay, this is really what we need for germinal centers because if you have 100 clones and each one is a different color, and then there is a strong selection event like a clone will sweep where one clone just starts dividing and takes over the whole thing,. You're going to see a germinal center that's multicolored turned into something that's single colored. With that, without any sequencing, just by looking at it, we are going to be able