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Immune 52: B cell boot camp with Gabriel Victora

Immune

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The Bottleneck in Antigen Recognition

The bottleneck is no longer what was maybe traditionally predicted where the bottleneck was that you wouldn't have this diverse germinal center in the beginning. They tend to span the whole range of mutations at that particular clone. So it seems more like how good the cell was to start with. Yeah, so the bottleneck is strong. It's just not where we thought it was.

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