Anyone who has a disorder that would be aggravated by caffeine is either dropped from the caffeine industry studies or buried under the mountain of mean values. This mythical person, upon whom all their conclusions are based, is neither male nor female. Consumes less than 300mg of caffeine per day and eats a well balanced diet including a variety of foods,. high in B vitamins, calcium, magnesium and zinc. Neither experience excessive stress with perfectly functioned adrenals and liver. Does not use birth control pills or any other caffeine interacting drugs.