The Decline of NAD Levels in the Elderly

So focusing on the NAMPT, you've got a 50% reduction over a 15-year period from 45 to 60. But it's worse than that because you've got the CD38 levels increasing and PARP activation going along with, so that synergistically contributes to the decline. So if you look at the curve, it's an exponential curve. And again, I just find that incredibly frightening because it is so important.