Mice that eat a high-fat diet but within 8 to 10 hours they're protected from many diseases. If these mice now give up their high- fat diet and eat normal chow within short period they will be even healthier. So that's why I always say that yes timing does matter but nutrition quality also matters. Then we'll come to nutrition quantity because there are also new experiments from Jotaka Hase's lab from UT South Western which shook up all the calorie restriction field.