IGF-Binding Protein 3 and Insulin

Methionine has probably been shown to be the most active amino acid in driving IGF pathway. As insulin levels go down, IGF-BP3 goes up as IGF-binding protein 3 goes up. So sex hormone binding globulin goes up when insulin goes down. That means if you have no change in testosterone level or even estradiol level, free testosterone will go down. It's for that reason that I think that insulin and carbohydrate do play an important role in the IGF pathway.

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