Limits of MPS as a hypertrophy proxy

In this episode of Hypertrophy Past & Present, Jake and Chris revisit the Silver Era through one of the most iconic Silver Era bodybuilders, John Grimek, and his bulking plan. They then discuss what muscle protein synthesis (MPS) and muscle protein breakdown (MPB) really mean, dismantling the idea that “elevated MPS = muscle growth”. 

Key topics include:

-John Grimek’s full-body gaining routine and the practical logic of Silver Era plans

-MPS vs MPB and net protein balance

-Why you can’t assume elevated MPS always reflects hypertrophy or protection from atrophy

-How steroids physiologically make dieting and comp prep "easier"