Challenges of Achieving Remission in Type 2 Diabetes

Episode #329. Boost metabolic health and prevent disease with expert insights from an all-star lineup of scientists. Learn key strategies for improving metabolic health, including metabolic flexibility, muscle health, and the critical roles of diet and exercise in preventing type 2 diabetes and fatty liver disease.

In this episode, you’ll hear from a distinguished panel of specialists including applied exercise physiologist Inigo San Millan, PhD; skeletal muscle expert Don Layman, PhD; type 2 diabetes authority Roy Taylor, PhD; dietitian and researcher Andrea Glenn, PhD, RD; nutrition scientist Alan Flanagan, PhD; nutrition scientist and endocrinologist Christos Mantzoros MD, DSc, PhD; and physician and researcher Richard Johnson, MD.

Specifically, we discuss:

• Intro (00:00)
• What is Metabolic Health (01:35)
• Metabolic Health, Mitochondria, Defining 'Metabolise', Metabolic Flexibility (07:02)
• The Importance of Skeletal Muscle for Metabolic Health (20:03)
• Exercise for metabolic health ****Zone 2 (28:36)
• Twin Cycle Hypothesis (56:45)
• Understanding the Personal Fat Threshold (01:08:15)
• Summary of the DiRECT Trial: Examining the Twin Cycle Hypothesis with Roy Taylor (01:17:08)
• Are DASH, Nordic, Mediterranean, and Portfolio diets good for preventing and managing diabetes? (01:36:46)
• Understanding Non-Alcoholic Fatty Liver Disease and Its Development (01:42:39)
• The Science of Hepatic Fat Oxidation (01:49:37)
• Consequences and Effects of Fatty Liver Disease (01:55:14)
• Linking Non-Alcoholic Fatty Liver Disease with Type 2 Diabetes (02:00:42)
• Combination of Fructose and Saturated fat on Metabolic Health (02:13:21)
• Type of fat and its effect on Metabolic Health (02:17:35)
• What cause Metabolic Health: fat or fructose (02:24:01)
• New Fat Storage Mechanisms - Personal Fat Threshold (02:27:50)
• Modern Techniques for Accurate Body Fat Measurement (02:31:52)
• Health metabolic biomarkers (02:36:51)
• Ectopic fat (02:38:19)
• Fat storage and metabolic health (02:39:10)
• Evolutionary Insights into Human Fat Storage (02:42:02)
• Fatty Liver Disease (02:45:46)
• Outro (2:57:46)

Connect with today’s guests and listen to their previous episodes at the links above.

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Simon Hill, MSc, BSc (Hons)

Creator of theproof.com and host of The Proof with Simon Hill

Author of The Proof is in the Plants

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