The Impact of Immune Aging and Urolithin A

Are you protecting your immune system as you age?

In this Longevity podcast episode, I am joined by Dr. Anurag Singh to discuss recent research that suggests Urolithin A, a compound derived from pomegranates and other foods, may help rejuvenate the aging immune system. 

We dive into how supplementing with Urolithin A for just 4 weeks led to significant improvements in immune cell function and a reduction in biological age by an average of 2 years in middle-aged adults. We also discuss insights on dosing, combining Urolithin A with other longevity strategies, and ongoing clinical trials that may reveal even more benefits.

Dr. Anurag Singh is the Chief Medical Officer of Timeline Nutrition, a biotech company focused on discovering and developing next generation natural compounds that target improvement in mitochondrial health. He began his career in 2003 as a Resident Medical Doctor at Northern Railway Divisional Hospital in Lucknow. 

Go to TimelineNutrition.com/nat10 and/or use code Nat10 for a discount.

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Find more from Dr. Singh/Timeline: 

Website: www.timelinenutrition.com 

Instagram: @timeline_longevity

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What We Discuss:

09:04 The Role of the Immune System in Aging

12:10 Understanding Immune Exhaustion and Inflammation

15:12 Mitochondrial Health and Immune Function

18:06 Urolithin A: Sources and Production

12:05 Research Studies on Urolithin A and Cancer

30:01 Clinical Trials and Future Directions

31:17 Understanding the Immune System

33:54 The Mitoimmune Randomized Control Trial

38:31 Dosing and Effects of Urolithin A

40:22 Biological Age Reversal and Longevity

44:33 Combining Strategies for Enhanced Benefits

49:21 Future Research Directions in Cancer and Neurodegeneration

Studies Mentioned: 

Mitochondrial Recycling Reverts Age-Associated Decline

Urolithin-A Promotes CD8+ T Cell–mediated Cancer Immunosurveillance

Expansion of T memory stem cells with superior anti-tumor immunity by Urolithin A-induced mitophagy

Mitopure Impact on Immune Aging: RCT