The Role of Leptin in Weight Gain

Most of the women that I work with, they have some degree of leptin insensitivity. Women are exquisitely sensitive to becoming more leptin insensitive just by proxy of being a woman. There's this bias where it's so much easier for women to gain weight than it is for them to lose weight compared to men. We evolved as women to have more fat to be fertile and we want to make enough luteinizing hormone so that we're ovulating every month.