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Placebo and No-Cebo Effects in Scientific Research
The natural history of disease or regression toward the mean is a powerful confounding factor in anecdotal evidence about wellness treatments. People tend to enroll in studies when their symptoms are quite bad so it's likely that no matter what treatment they're given, their symptoms are going to improve. Placebo and no-cebo effects are also important to confounders in scientific research on diets and on many other integrative and functional medicine interventions.