12min chapter

The Peter Attia Drive cover image

#312 - A masterclass in lactate: Its critical role as metabolic fuel, implications for diseases, and therapeutic potential from cancer to brain health and beyond | George A. Brooks, Ph.D.

The Peter Attia Drive

CHAPTER

Lactate: Beyond a Metabolic Byproduct

This chapter explores the complexities of lactate production, its effects on acid-base balance, and its role in gene regulation through lactylation. The discussion highlights the implications of lactate on muscle cells, metabolic health, and cognitive function, emphasizing the differences between endogenous and exogenous lactate. It also proposes innovative research designs to further investigate lactate's potential benefits, particularly in the context of exercise and recovery from traumatic brain injury.

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