Navigating Methotrexate and Folate Supplementation

This chapter explores the critical role of folate supplementation in patients receiving methotrexate, emphasizing the importance of appropriate dosing to reduce toxicity. It discusses various administration strategies for folate and leucovorin, as well as personal observations on mitigating side effects like nausea and oral ulcers. Additionally, the chapter examines the effectiveness of different dosing regimens and routes for methotrexate, particularly when used alongside biologic therapies for autoimmune conditions.