The total cost of muscular skeletal system injury and recovery rehab in the US is close to a trillion dollar. That's almost two to three times more than what we spend on cancer, which is something that's overlooked. Our musculoskeletal system with our bones of a circadian clock tunes how much of bone is degraded every day and how much of new bone is formed. Same thing goes on in the ligament. Tendon, the extracellular matrix, the glue that gives things together, it actually has to recycle. And the muscle function, so that's how we can go back to the circadian rhythm.