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The Evolution of Senescent Cells
There's a lot of diversity of senescent cells. There's different sort of subtypes and successfully targeting them is kind of analogous to the cancer cell problem, right? You need something that will only kill the cancer cells. But in the senescent cell case, you have less of a tolerance for toxicity because you're dealing with otherwise healthy people. What the hell makes cells get senescent in the first place? Yes. That's an interesting one. I find it useful to talk about Nacim Talib's coinage of antifragility. A phoenix is robust and a hydra is antifragile because, you know, you cut off a head and grows another one