Mixing Rep Ranges Too Much in a Single Workout Might Have Some Downsides

The direct literature on this with James Krieger summed up very well is completely it's not even inconclusive. We know that the different rep ranges may activate slightly different pathways for example we know from animal models that concentric training eccentric training and isometric training all activate a lot of the same pathways of hypertrophy but all actually activates some different ones too. So our physiological rationale probably leads us to believe that mixing rep ranges too much in a single workout might have some downsidesactually not upside sides doing different rep ranges in the same week, probably about 5050 upsides downsides. It becomes a problem excessive diversity never settle in. And so I think there's almost certainly no benefit

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