Promising Drugs: Rapamycin & Metformin

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Scientist and author Dr. Andrew Steele joins James Smith to tackle the problem with aging and why dying of “old age” might one day be seen as a preventable condition. Andrew breaks down the science of longevity, the myths around “anti-aging,” and the difference between fundamental research and influencer nonsense. He explains how new medical breakthroughs could help humans live healthier for far longer, but also why the hype around biohacking and “forever pills” is getting dangerously ahead of the science.

They explore the ethical, political, and even economic implications of extending human life, from billionaire-funded immortality labs to the fear that longevity could deepen inequality. Andrew reveals what the real science shows about genes, lifestyle, and luck; why exercise is still the best anti-aging treatment we have; and how new drugs like GLP-1 agonists could transform global health and longevity.

He explains:

◼️ Why 90% of deaths in rich countries are caused by aging

◼️ The truth about genetic luck vs lifestyle choices

◼️ How longevity drugs could revolutionise healthcare

◼️ Why “anti-ageing” influencers are misleading the public

◼️ The shocking economics of living to 100… or beyond

Chapters

00:00 Why Men Die Earlier Than Women

01:31 The Real Problem With Aging

02:36 Separating Longevity Fact From Fiction

05:23 What Your Face Reveals About Health

08:50 How Much Do Genetics Actually Matter?

12:32 Do Weight Loss Drugs Slow Aging?

16:48 The Stigma Of Weight Loss Drugs

19:01 James’ Experience Taking Weight Loss Drugs

22:37 Is Taking Ozempic "Cheating"?

27:02 The Reality Of Maintaining Weight Loss

31:26 Why Modern Diets Are Failing

35:26 The Future Of Longevity Medicine

39:36 Will Longevity Increase Retirement Age?

43:01 The Problem With Bryan Johnson’s Protocol

46:44 Is Biohacking Just An Eating Disorder?

52:01 The Dangers Of Over-Optimizing Health

56:36 Does Health Anxiety Shorten Lifespan?

01:01:46 The Truth About HRT For Women

01:06:51 Does Testosterone Shorten Men’s Lives?

01:12:50 Why Eunuchs Live Longer Than Men

01:17:56 The Philosophy Of Living Forever

01:27:11 The Most Effective Longevity Habits

01:29:56 Does Intermittent Fasting Increase Longevity?

01:38:36 The Most Promising Anti-Aging Drug

01:45:36 The Economic Case For Curing Aging

Welcome to "The Problem With" where each week we look into a problem to get a better understanding of it. This podcast has no sponsors, only my businesses and investments. Please check out the links below.

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