REBEL Cast Ep 118: The PROCOAG Trial – 4F-PCC for Trauma Patients?
REBEL Cast
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The Limitations of 24-Hour Blood Product Use
Swami: The groups were well balanced in terms of characteristics, pre-hospital vital signs. They did a good job with a pragmatic inclusion criteria so they could recruit as many of these severe bleeding patients as they could. Swami: There's just a couple that I think are worth reviewing. We mentioned this already, but the primary outcome of 24-hour blood product use is not patient-centered.
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Background: Hemorrhage is the leading cause of mortality in trauma patients. Interventions such as early application of hemorrhage control, tranexamic acid, reduction of crystalloid fluid administration and balanced ratio blood product transfusion have improved many patients’ outcomes. However, mortality still remains high due to trauma-induced coagulopathy. Some clinicians have advocated for early administration of 4-factor ... 
