Adavan Aspan, Remi Maselam, and Medasilam

Benzos reduce muscular tone in the upper airway and put patients at risk for obstruction. Adavan aspan is conjugated in the liver, not by the c y p system,. So renal impairment doesn't prolong its action because it won't be conjugated. An infusion of adivan is a problem overtime, because it's in propoline glycal. And so you can actually get propoline glyCal toxicity from an adivan infusion. Remi maselam, interestingly, is a new benzo deasapine, which, like remi fentonel, is cleared and broken down by non specific tissue esterases. We may see that more in the future