The Role of Free Fatty Acids in Diabetes

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Excess lipolysis, excess free fatty acids in the blood trigger the periphery to become insulin resistant. There's actually a very fascinating condition called Dunnegan familial lipodistrophe. People with this can get very fat on very low calories or they're it's really fascinating. They have increased rates of cardiovascular disease with no increased levels of LDL. The dysfunction at the level of our fat cells is what causes diabetes.

This week, Paul has Georgi Dinkov back on the podcast for the third time to cover a plethora of topics: the benefits versus risks of carbohydrates, polyunsaturated fatty acids in cell membranes, the root causes of diabetes and cancer, and so much more.

00:08:45 Raising children in the modern world

00:10:10 Can we extend our lifespan through fasting and Metformin?

00:18:40 High intensity interval training and other kinds of exercise

00:24:10 Protein, glycine, and preventing sarcopenia

00:30:30 Inflammation and endotoxins

00:39:10 Stop fearing blood glucose levels

00:43:10 Downsides of fasting and how to obtain autophagy

01:01:05 Thoughts on metformin

01:10:03 What causes diabetes?

01:28:50 Polyunsaturated fats behave differently than saturated fats

01:32:54 The Rice Diet

01:40:32 Thoughts on exercise