Noninferiority Trials: Is a New Treatment Almost as Effective as Another? with Dr Amy Kaji
JAMAevidence JAMA Guide to Statistics and Methods
Differences between noninferiority and superiority trials
This chapter explores the distinctions between noninferiority trials and superiority trials, highlighting the varying sample size requirements and margin allowances. Additionally, it emphasizes the potential impact of unrealistic differences chosen by researchers on patient numbers in a trial.
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