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#47 – A Nefarious Orchestra: Gram-Negative Resistance Mechanisms Part 2

Breakpoints

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Oxa 23 and Oxa Ten Derivatives

The reaction mechanism for an oxenzyne is identically symmetric. The licene at the 70 position is carbamelated, and that means it's got an extra seal group on it. And when you bring that type of catalysis to the scene, and then you build a hydrophobic bridge in oxa enzines, they're not really great at hydralizing carba peems. When you put them in a bug like asined or bactor, that's ten times harder to put an anabiotic through its ou e membrane.

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