Epithelioids: A Breakthrough in Epithelial Culture

This chapter explores a novel organoid-like system, epithelioids, designed for the long-term culture of epithelial cells, highlighting their unique capabilities and implications for studying epithelial mutations and cancer. It delves into a significant CRISPR screen that investigates clonal expansion in the esophageal epithelium, emphasizing the potential applications of this new model in pharmaceutical research.