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Coke's Posholots
Coke, aware of germ theory but not completely convinced, decided to examine the blood of some sheep who had recently died in an anthrax epidemic. To his surprise, he saw millions of rod-shaped bacteria under the microscope. Not wanting to jump the gun, which was unlike pretty much every other scientist during this time, he said about designing a series of experiments which would conclusively show that anthrax was caused by bacilli. And these, dear listeners, are what is known as Coke's Posholots.