Trials of the Week: Nimodipine Landmark Studies
Pharmacy to Dose: The Critical Care Podcast
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Landmark Study on Nimodipine and Subarachnoid Hemorrhage
The chapter delves into a landmark study published in the British Medical Journal in the 80s that examined the effects of oral nimodipine on cerebral infarction and outcomes following subarachnoid hemorrhage. It discusses the trial methodology, findings, and ongoing debates on the administration of nimodipine, emphasizing its role in improving functional outcomes despite questions about universal administration and dosing consistency. The chapter also touches on the challenges of conducting randomized controlled trials in critical care settings, citing variability in pharmacokinetics and ongoing research in neurocritical care.
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