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World-renowned longevity and mitochondrial health expert Dr. Anurag Singh joins David in this bonus episode to demystify one of the most critical yet overlooked components of your health—your mitochondria. Known as the powerhouses of your cells, these microscopic engines fuel everything from your brain to your biceps. But as you age, poor lifestyle choices, stress, processed food, and common medications can damage your mitochondria—leaving you tired, inflamed, and susceptible to disease.
Dr. Singh explains how mitochondria evolved from ancient bacteria, why their decline is a key hallmark of aging, and the three essential strategies to boost mitochondrial health: biogenesis (creating new mitochondria), efficiency (improving function), and mitophagy (clearing out the damaged ones).
He dives deep into supplementation protocols, highlighting compounds like resveratrol, NAD boosters (NR, NMN), CoQ10, and creatine, while also introducing urolithin A—a breakthrough postbiotic compound derived from pomegranates and developed into the clinically-backed supplement Mitopure by his team at Timeline Nutrition.
David and Dr. Singh also explore the powerful connection between the gut microbiome and mitochondrial health, why different cultures like the Dutch and Japanese age more gracefully, and why antibiotics, statins, steroids, and sedentary lifestyles are silently sabotaging your energy.
Whether you’re an elite athlete, biohacker, or someone just trying to feel better and age stronger—this episode is packed with actionable science and timeless wisdom.
CHAPTERS:
00:00 Mitochondria Explained: The Cellular Powerhouse
04:35 What Happens to Mitochondria as We Age
07:55 The Three Pillars of Mitochondrial Optimization
11:32 Red Wine, Resveratrol, and the Truth About Nutrition
15:45 NAD Boosters and Raw Milk: Myths vs. Science
19:20 The Perfect Mitochondrial Supplementation Cocktail
22:40 Why Cultures with Better Gut Health Age Better
27:55 Statins, Steroids & Processed Food: Hidden Energy Killers
31:10 Exercise Compliance and Overtraining in Athletes
34:05 The Discovery of Urolithin A and Its Power
38:45 Timeline Nutrition & Testing Your Gut’s Postbiotic Potential
42:30 The Future of Mitochondrial Science and Human Longevity
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