Getting at True Heritability | Alexander Young & Richard Hanania
CSPI Podcast
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Is the GWAS a Twin Method?
So, what we were talking about is trying to estimate heritability. What we might want to do is actually pinpoint specific variations in the genome that have an effect on a phenotype like height or educational attainment. The most common way to do that is a study design called the genome wide association study. It scans across potentially millions of different genetic variants across the genome. And it tries to estimate what the effect of changing from one version of that genetic variant to another is at each position in the genome. By doing that, we can build genetic predictors often called polygenic scores to predict the phenotype from the genotype.
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