AI-powered
podcast player
Listen to all your favourite podcasts with AI-powered features
5min chapter
#133 – Manolis Kellis: Biology of Disease
Lex Fridman Podcast
Is There an Enrichment in Meiosis?
For every single disease that we've looked at, we have found an epigenomic enrichment. How do you do that? You basically have all of the genetic variants associated with the disorder, and then you're asking for all of the enhancers active in a particular tissue. For FTO, it wasn't just one variant, it was 89 common variants that were all humongously associated with obesity. And if you eat a lot but don't exercise too much, there's excess energy which leads to obesity. So when you overeat or not exercise enough, your body creates high-energy molecules called lipids who can burn calories on rainy days. These are the cells that store energy from eating
00:00
Transcript
Episode notes
Get the Snipd
podcast app
Unlock the knowledge in podcasts with the podcast player of the future.
AI-powered
Discover
highlights
Listen to the best highlights from the podcasts you love and dive into the full episode
Save any
moment
Hear something you like? Tap your headphones to save it with AI-generated key takeaways
Share
& Export
Send highlights to Twitter, WhatsApp or export them to Notion, Readwise & more
AI-powered
podcast player
Listen to all your favourite podcasts with AI-powered features
Discover
highlights
Listen to the best highlights from the podcasts you love and dive into the full episode