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Ep. 79: “ILC2s, the Microbiome, and Fibroblasts” Featuring Dr. Kellen Cavagnero

The Immunology Podcast

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Unraveling RIPK1 and Immune Cell Development

This chapter explores the multifaceted role of RIPK1 in immune responses and cancer cell survival, focusing on a novel RIPK1-specific protac degrader that enhances anti-tumor activities. It also discusses significant findings from a study on severe combined immunodeficiency and its link to genetic mutations, elucidating their implications for immune cell function. The chapter highlights the importance of the NUDCD3 gene in T and B cell receptor recombination, drawing connections to immune-related disorders and potential treatment pathways.

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