3min chapter

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#144 – Athena Aktipis on why cancer is actually one of our universe's most fundamental phenomena

80,000 Hours Podcast

CHAPTER

The Cell Puts So Many Eggs in One Basket

The TP53 gene collects a lot of information about what's going on in the cell and in the local environment to decide whether the cell should commit suicide. Because so much work is being done by this one TP53 gene protein, that creates a single point of failure where if you have a really destructive mutation in the TP53 gene such that it cannot function anymore, then your chances of that cell becoming cancerous go way up. So why not have lots of different processes going on at the same time, all independently deciding whether something has gone wrong?

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